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OCR: hosphate There is no abnormality in calcium or d increase homeostasis. There is, however, a mar ne is an in urinary hydroxyproline (hydroxypro gen, and amino acid that is almost unique to col turnover) urinary excretion reflects increased bon and serum alkaline phosphatase. Alkal ed by phosphatase is an enzyme that is produ sed osteoblasts and its increase reflects incn osteoblastic activity.